Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HER-2/neu mediates oncogenic transformation via altered CREB expression and function.

Molecular cancer research : MCR - 1 Nov 2013

Steven André, Leisz Sandra, Massa Chiara, Iezzi Manuela, Lattanzio Rossano, Lamolinara Alessia, Bukur Jürgen, Müller Anja, Hiebl Bernhard, Holzhausen Hans-Jürgen, Seliger Barbara

Abstract excerpt

UNLABELLED: The cyclic (c)AMP responsive element binding protein (CREB) plays a key role in many cellular processes, including differentiation, proliferation, and signal transduction. Furthermore, CREB overexpression was found in tumors of distinct origin and evidence suggests an association with tumorigenicity. To establish a mechanistic link between HER-2/neu-mediated transformation and CREB protein expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Cyclic AMP Response Element-Binding Protein

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mammary Neoplasms, Experimental

Share to MCF-7 Cells

Share to Mice, Inbred DBA

Share to NIH 3T3 Cells

Share to Receptor, ErbB-2

Share to Tissue Array Analysis

Source

Identifiers

PMID: 24025972
DOI: 10.1158/1541-7786.MCR-13-0125

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HER-2/neu mediates oncogenic transformation via altered CREB expression and function.PMID 24025972Read ↗

Control of CREB expression in tumors: from molecular mechanisms and signal transduction pathways to therapeutic targetSemantic proximity Read ↗

Noncanonical UPR factor CREB3L2 drives immune evasion of triple-negative breast cancer through Hedgehog pathway modulation in T cellsSemantic proximity Read ↗

HER‐2/ <i>neu</i> Signal Transduction in Human Breast and Ovarian CancerSemantic proximity Read ↗

HER-2/neu-mediated Down-regulation of Biglycan Associated with Altered Growth PropertiesSemantic proximity Read ↗

CREB in the Pathophysiology of Cancer: Implications for Targeting Transcription Factors for Cancer TherapySemantic proximity Read ↗

Targeting CREB for Cancer Therapy: Friend or FoeSemantic proximity Read ↗

Proteomic characterization of differentially expressed proteins in breast cancer: Expression of hnRNP H1, RKIP and GRP78 is strongly associated with HER-2/neu status.Semantic proximity Read ↗

Oncogenic Signals of HER-2/neu in Regulating the Stability of the Cyclin-dependent Kinase Inhibitor p27Semantic proximity Read ↗

Downregulation of CREB Promotes Cell Proliferation by Mediating G<sub>1</sub>/S Phase Transition in Hodgkin LymphomaSemantic proximity Read ↗

CREB1 activation promotes human papillomavirus oncogene expression and cervical cancer cell transformationSemantic proximity Read ↗

Selective CREB-dependent cyclin expression mediated by the PI3K and MAPK pathways supports glioma cell proliferationSemantic proximity Read ↗

Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.