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Article

Neuregulins and Cancer

1 Jun 2008

Abstract excerpt

The neuregulins represent the largest subclass of polypeptide factors of the epidermal growth factor family of ligands. These molecules are synthesized as membrane-bound, biologically active growth factors that act by binding to the HER/ErbB receptor tyrosine kinases. Preclinical data have indicated that increased expression and function of neuregulins may provoke cancer. Furthermore, neuregulin expression has...

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PMID: 18519747
DOI: 10.1158/1078-0432.ccr-07-5133

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