Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2001

Beeton C, Wulff H, Barbaria J, Clot-Faybesse O, Pennington M, Bernard D, Cahalan M D, Chandy K G, Béraud E

Abstract excerpt

Adoptive transfer experimental autoimmune encephalomyelitis (AT-EAE), a disease resembling multiple sclerosis, is induced in rats by myelin basic protein (MBP)-activated CD4(+) T lymphocytes. By patch-clamp analysis, encephalitogenic rat T cells stimulated repeatedly in vitro expressed a unique channel phenotype ("chronically activated") with large numbers of Kv1.3 voltage-gated channels (approximately 1500 per...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Channel Blockers
Share to Encephalomyelitis, Autoimmune, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guinea Pigs

Share to Isotope Labeling

Share to Potassium Channel Blockers

Share to Rats, Inbred Lew

Share to Thymidine

Share to Tritium

Source

Open in PubMed Open full text

Identifiers

PMID: 11717451
DOI: 10.1073/pnas.241497298
PMCID: PMC61146

Genes

MBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis.PMID 11717451Read ↗

Potassium channels as therapeutic targets for autoimmune disorders.Semantic proximity Read ↗

The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS.Semantic proximity Read ↗

Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis.Semantic proximity Read ↗

A Novel Fluorescent Toxin to Detect and Investigate Kv1.3 Channel Up-regulation in Chronically Activated T LymphocytesSemantic proximity Read ↗

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions.Semantic proximity Read ↗

Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties.Semantic proximity Read ↗

TRPV1 gates tissue access and sustains pathogenicity in autoimmune encephalitis.Semantic proximity Read ↗

Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms.Semantic proximity Read ↗

The Disease-Ameliorating Function of Autoregulatory CD8 T Cells Is Mediated by Targeting of Encephalitogenic CD4 T Cells in Experimental Autoimmune EncephalomyelitisSemantic proximity Read ↗

State-dependent blocking mechanism of Kv 1.3 channels by the antimycobacterial drug clofazimine.Semantic proximity Read ↗

Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosusSemantic proximity Read ↗

Nanovesicle-targeted Kv1.3 knockdown in memory T cells suppresses CD40L expression and memory phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.