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Article

Analysis of NPR-1 reveals a circuit mechanism for behavioral quiescence in C. elegans.

Neuron - 5 Jun 2013

Choi Seungwon, Chatzigeorgiou Marios, Taylor Kelsey P, Schafer William R, Kaplan Joshua M

Abstract excerpt

Animals undergo periods of behavioral quiescence and arousal in response to environmental, circadian, or developmental cues. During larval molts, C. elegans undergoes a period of profound behavioral quiescence termed lethargus. Locomotion quiescence during lethargus was abolished in mutants lacking a neuropeptide receptor (NPR-1) and was reduced in mutants lacking NPR-1 ligands (FLP-18 and FLP-21). Wild-type...

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PMID: 23764289
DOI: 10.1016/j.neuron.2013.04.002
PMCID: PMC3683153

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Source receipt: pubmed, retrieved 7 Sept 2026.

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