Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans.

Nature neuroscience - 1 Oct 2008

Ringstad Niels, Horvitz H Robert

Abstract excerpt

Egg-laying behavior of the Caenorhabditis elegans hermaphrodite is regulated by G protein signaling pathways. Here we show that the egg laying-defective mutant egl-6(n592) carries an activating mutation in a G protein-coupled receptor that inhibits C. elegans egg-laying motor neurons in a G(o)-dependent manner. Ligands for EGL-6 are Phe-Met-Arg-Phe-NH(2) (FMRFamide)-related peptides encoded by the genes flp-10...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholine
Share to Alanine
Share to Membrane Potentials

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Motor Neurons

Share to Neural Inhibition

Share to Patch-Clamp Techniques

Share to Receptors, G-Protein-Coupled

Share to Threonine

Source

Open in PubMed Open full text

Identifiers

PMID: 18806786
DOI: 10.1038/nn.2186
PMCID: PMC2963311

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans.PMID 18806786Read ↗

IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway.Semantic proximity Read ↗

Activation of EGL-47, a Galpha(o)-coupled receptor, inhibits function of hermaphrodite-specific motor neurons to regulate Caenorhabditis elegans egg-laying behavior.Semantic proximity Read ↗

NeuropeptidesSemantic proximity Read ↗

PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying.Semantic proximity Read ↗

egl-4 acts through a transforming growth factor-beta/SMAD pathway in Caenorhabditis elegans to regulate multiple neuronal circuits in response to sensory cues.Semantic proximity Read ↗

Genetic and cellular basis for acetylcholine inhibition of Caenorhabditis elegans egg-laying behavior.Semantic proximity Read ↗

Intestinal signaling to GABAergic neurons regulates a rhythmic behavior in Caenorhabditis elegans.Semantic proximity Read ↗

Multiple RGS proteins alter neural G protein signaling to allow C. elegans to rapidly change behavior when fed.Semantic proximity Read ↗

LIN-12/Notch Regulates GABA Signaling at the Caenorhabditis elegans Neuromuscular Junction.Semantic proximity Read ↗

FMRFamide-like peptides expand the behavioral repertoire of a densely connected nervous system.Semantic proximity Read ↗

Localization of FMRFamide-like peptides in Caenorhabditis elegans.Semantic proximity Read ↗

Caenorhabditis elegans Galphaq regulates egg-laying behavior via a PLCbeta-independent and serotonin-dependent signaling pathway and likely functions both in the nervous system and in muscle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.