FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans.

doi:10.1038/nn.2186

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Article

FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans.

Nature neuroscience - 1 Oct 2008

Ringstad Niels, Horvitz H Robert

Abstract excerpt

Egg-laying behavior of the Caenorhabditis elegans hermaphrodite is regulated by G protein signaling pathways. Here we show that the egg laying-defective mutant egl-6(n592) carries an activating mutation in a G protein-coupled receptor that inhibits C. elegans egg-laying motor neurons in a G(o)-dependent manner. Ligands for EGL-6 are Phe-Met-Arg-Phe-NH(2) (FMRFamide)-related peptides encoded by the genes flp-10...

Topics

Acetylcholine
Alanine
Animals
Animals, Genetically Modified
Behavior, Animal
Caenorhabditis elegans
Caenorhabditis elegans Proteins
FMRFamide
Female
Gene Expression Regulation
Green Fluorescent Proteins
Membrane Potentials
Membrane Transport Modulators
Motor Neurons

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Identifiers

PMID: 18806786
DOI: 10.1038/nn.2186
PMCID: PMC2963311

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Mutation

Neural Inhibition

Patch-Clamp Techniques

Peptides