Article
Tumor promoting effect of podoplanin-positive fibroblasts is mediated by enhanced RhoA activity.
Biochemical and biophysical research communications - 25 May 2012
Ito Suguru, Ishii Genichiro, Hoshino Ayuko, Hashimoto Hiroko, Neri Shinya, Kuwata Takeshi, Higashi Morihiro, Nagai Kanji, Ochiai Atsushi
Abstract excerpt
There is growing evidence that stromal fibroblasts can promote tumor progression via several mechanisms. We previously reported that podoplanin (PDPN) expressed on stromal fibroblasts is functionally protein responsible for the promotion of tumor formation in mouse subcutaneous tissue. The purpose of the present study was to reveal the molecular mechanism by which PDPN on stromal fibroblasts promotes tumor...
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