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Article

Induction of podoplanin by transforming growth factor‐β in human fibrosarcoma

26 Dec 2007

Abstract excerpt

Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential. However, regulators of podoplanin remain to be determined. Transforming growth factor-beta (TGF-beta) regulates many physiological events, including tumorigenesis. Here, we found that TGF-beta...

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PMID: 18158922
DOI: 10.1016/j.febslet.2007.12.028

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