Article
Podoplanin-positive cancer-associated fibroblasts in the tumor microenvironment induce primary resistance to EGFR-TKIs in lung adenocarcinoma with EGFR mutation.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2015
Yoshida Tatsuya, Ishii Genichiro, Goto Koichi, Neri Shinya, Hashimoto Hiroko, Yoh Kiyotaka, Niho Seiji, Umemura Shigeki, Matsumoto Shingo, Ohmatsu Hironobu, Iida Shinsuke, Niimi Akio, Nagai Kanji, Ohe Yuichiro, Ochiai Atsushi
Abstract excerpt
PURPOSE: The biologic characteristics of microenvironmental constituents, especially cancer-associated fibroblasts (CAF), can be key regulators of the cellular sensitivity to molecular-targeted therapy. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) have marked therapeutic effects against non-small cell lung cancer (NSCLC) with EGFR mutations, but some patients have exhibited primary...
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