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Stromal transforming growth factor-beta 1 is crucial for reinforcing the invasive potential of low invasive cancer.

Archives of oral biology - 1 Jul 2014

Hwang Young Sun, Park Kwang-Kyun, Chung Won-Yoon

Abstract excerpt

OBJECTIVE: Tumour cells alter the characteristics of the adjacent stroma to create a supportive microenvironment during cancer progression. In vitro and in vivo experiments were carried out to verify the role of stromal TGF-β1 in reinforcing of the invasive potential in low invasive cancer. MATERIALS AND METHODS: Isolated NF or CAF was co-cultured with low invasive HSC-2 cells to evaluate whether stromal TGF-β1...

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PMID: 24769314
DOI: 10.1016/j.archoralbio.2014.03.017

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