Article
Blockade of four-transmembrane L6 family member 5 (TM4SF5)-mediated tumorigenicity in hepatocytes by a synthetic chalcone derivative.
Hepatology (Baltimore, Md.) - 1 Apr 2009
Lee Sin-Ae, Ryu Hyung Won, Kim Young Mee, Choi Suyong, Lee Mi Ji, Kwak Tae Kyoung, Kim Hyeon Jung, Cho Moonjae, Park Ki Hun, Lee Jung Weon
Abstract excerpt
UNLABELLED: We previously reported that the four-transmembrane L6 family member 5 (TM4SF5) was highly expressed in hepatocarcinoma, induced morphological elongation and epithelial-mesenchymal transition, and caused abnormal cell growth in multilayers in vitro and tumor formation in vivo. In this study, we identified a synthetic compound, 4'-(p-toluenesulfonylamido)-4-hydroxychalcone (TSAHC) that antagonized both...
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