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Article

S-allyl-glutathione improves experimental liver fibrosis by regulating Kupffer cell activation in rats.

American journal of physiology. Gastrointestinal and liver physiology - 1 Feb 2018

Takemura Shigekazu, Azuma Hideki, Osada-Oka Mayuko, Kubo Shoji, Shibata Toshihiko, Minamiyama Yukiko

Abstract excerpt

S-allyl-glutathione (SAG) is one of the metabolites of diallyl sulfide (DAS), a component of garlic. DAS has shown preventative effects on carcinogenesis in animal models. However, whether synthetic SAG can improve liver fibrosis has not been investigated. We examined the potential preventive effects of SAG on acute and chronic models of liver fibrosis by chronic carbon tetrachloride (CCl4) administration. SAG...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Collagen Type I, alpha 1 Chain

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Source

Identifiers

PMID: 28971836
DOI: 10.1152/ajpgi.00023.2017

Genes

SAG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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