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Article

Ethanol alters mechanosensory habituation in C. elegans by way of the BK potassium channel through a novel mechanism.

PloS one - 1 Jan 2025

Kokan Nikolas, Lin Conny, Luna Alvaro, Viliunas Joani, Rankin Catharine H

Abstract excerpt

In this research, we investigated how alcohol modulates the simplest form of learning, habituation, in Caenorhabditis elegans. We used our high throughput Multi-Worm Tracker to conduct a large scale study of more than 21,000 wild-type worms to assess the effects of different concentrations of alcohol on habituation of the well-characterized tap withdrawal response. We found that the effect of alcohol on...

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Topics

Animals
Caenorhabditis elegans
Ethanol
Large-Conductance Calcium-Activated Potassium Channels
Caenorhabditis elegans Proteins
Habituation, Psychophysiologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mechanotransduction, Cellular

Mutation

Source

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Identifiers

PMID: 40498794
DOI: 10.1371/journal.pone.0315069
PMCID: PMC12157217

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