Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Specific CD8+ T cell responses correlate with control of simian immunodeficiency virus replication in Mauritian cynomolgus macaques.

Journal of virology - 1 Jul 2012

Budde Melisa L, Greene Justin M, Chin Emily N, Ericsen Adam J, Scarlotta Matthew, Cain Brian T, Pham Ngoc H, Becker Ericka A, Harris Max, Weinfurter Jason T, O'Connor Shelby L, Piatak Michael, Lifson Jeffrey D, Gostick Emma, Price David A, Friedrich Thomas C, O'Connor David H

Abstract excerpt

Specific major histocompatibility complex (MHC) class I alleles are associated with an increased frequency of spontaneous control of human and simian immunodeficiency viruses (HIV and SIV). The mechanism of control is thought to involve MHC class I-restricted CD8(+) T cells, but it is not clear whether particular CD8(+) T cell responses or a broad repertoire of epitope-specific CD8(+) T cell populations (termed T...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Enzyme-Linked Immunospot Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, MHC Class I

Share to Macaca fascicularis

Share to Sequence Analysis, RNA

Share to Simian Acquired Immunodeficiency Syndrome

Share to Simian Immunodeficiency Virus

Share to Viral Regulatory and Accessory Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22573864
DOI: 10.1128/JVI.00716-12
PMCID: PMC3416303

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specific CD8+ T cell responses correlate with control of simian immunodeficiency virus replication in Mauritian cynomolgus macaques.PMID 22573864Read ↗

Mauritian cynomolgus macaques share two exceptionally common major histocompatibility complex class I alleles that restrict simian immunodeficiency virus-specific CD8+ T cells.Semantic proximity Read ↗

Simian immunodeficiency virus SIVmac239 infection of major histocompatibility complex-identical cynomolgus macaques from Mauritius.Semantic proximity Read ↗

Ex vivo SIV-specific CD8 T cell responses in heterozygous animals are primarily directed against peptides presented by a single MHC haplotype.Semantic proximity Read ↗

Patterns of CD8+ immunodominance may influence the ability of Mamu-B*08-positive macaques to naturally control simian immunodeficiency virus SIVmac239 replication.Semantic proximity Read ↗

Acute-phase CD4+ T cell responses targeting invariant viral regions are associated with control of live-attenuated simian immunodeficiency virusSemantic proximity Read ↗

Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.Semantic proximity Read ↗

Maintenance of AP-2-Dependent Functional Activities of Nef Restricts Pathways of Immune Escape from CD8 T Lymphocyte Responses.Semantic proximity Read ↗

The major histocompatibility complex class II alleles Mamu-DRB1*1003 and -DRB1*0306 are enriched in a cohort of simian immunodeficiency virus-infected rhesus macaque elite controllers.Semantic proximity Read ↗

Whole genome sequencing of SIV-infected macaques identifies candidate loci that may contribute to host control of virus replicationSemantic proximity Read ↗

Unusually high frequency MHC class I alleles in Mauritian origin cynomolgus macaques.Semantic proximity Read ↗

Long-Term Control of Simian Immunodeficiency Virus (SIV) in Cynomolgus Macaques Not Associated with Efficient SIV-Specific CD8<sup>+</sup>T-Cell ResponsesSemantic proximity Read ↗

CD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.