Article
Ex vivo SIV-specific CD8 T cell responses in heterozygous animals are primarily directed against peptides presented by a single MHC haplotype.
PloS one - 1 Jan 2012
Greene Justin M, Chin Emily N, Budde Melisa L, Lhost Jennifer J, Hines Paul J, Burwitz Benjamin J, Broman Karl W, Nelson Jennifer E, Friedrich Thomas C, O'Connor David H
Abstract excerpt
The presence of certain MHC class I alleles is correlated with remarkable control of HIV and SIV, indicating that specific CD8 T cell responses can effectively reduce viral replication. It remains unclear whether epitopic breadth is an important feature of this control. Previous studies have sugg...
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