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Tissue-Specific Methylation of Human Insulin Gene and PCR Assay for Monitoring Beta Cell Death

10 Apr 2014

Abstract excerpt

The onset of metabolic dysregulation in type 1 diabetes (T1D) occurs after autoimmune destruction of the majority of pancreatic insulin-producing beta cells. We previously demonstrated that the DNA encoding the insulin gene is uniquely unmethylated in these cells and then developed a methylation-specific PCR (MSP) assay to identify circulating beta cell DNA in streptozotocin-treated mice prior to the rise in...

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PMID: 24722187
DOI: 10.1371/journal.pone.0094591

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