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Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets

22 Nov 2010

Abstract excerpt

AIMS/HYPOTHESIS: Although recent studies propose that epigenetic factors influence insulin expression, the regulation of the insulin gene in type 2 diabetic islets is still not fully understood. Here, we examined DNA methylation of the insulin gene promoter in pancreatic islets from patients with type 2 diabetes and non-diabetic human donors and related it to insulin expression, HbA(1c) levels, BMI and age....

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Share to Epigenetics and DNA Methylation
Share to Genetic Associations and Epidemiology
Share to Pancreatic function and diabetes

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PMID: 21104225
DOI: 10.1007/s00125-010-1967-6

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