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Increased DNA methylation levels of the insulin-like growth factor binding protein 1 gene are associated with type 2 diabetes in Swedish men

19 Nov 2013

Abstract excerpt

BACKGROUND: Prospective studies have shown that low levels of circulating insulin-like growth factor binding protein-1 (IGFBP-1) are associated with the risk of type 2 diabetes. In the present study, we investigated DNA methylation in the IGFBP1 gene to evaluate its changes in relation to serum IGFBP-1 levels in type 2 diabetes. RESULTS: A total of 406 Swedish men, including age-matched normal glucose tolerance...

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PMID: 24246027
DOI: 10.1186/1868-7083-5-21

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