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Article

Identity by descent mapping of founder mutations in cancer using high-resolution tumor SNP data.

PloS one - 1 Jan 2012

Letouzé Eric, Sow Aliou, Petel Fabien, Rosati Roberto, Figueiredo Bonald C, Burnichon Nelly, Gimenez-Roqueplo Anne-Paule, Lalli Enzo, de Reyniès Aurélien

Abstract excerpt

Dense genotype data can be used to detect chromosome fragments inherited from a common ancestor in apparently unrelated individuals. A disease-causing mutation inherited from a common founder may thus be detected by searching for a common haplotype signature in a sample population of patients. We present here FounderTracker, a computational method for the genome-wide detection of founder mutations in cancer using...

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Identifiers

PMID: 22567117
DOI: 10.1371/journal.pone.0035897
PMCID: PMC3342326

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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