Article
4q loss is potentially an important genetic event in MM tumorigenesis: identification of a tumor suppressor gene regulated by promoter methylation at 4q13.3, platelet factor 4.
Blood - 1 Mar 2007
Cheng Suk Hang, Ng Margaret H L, Lau Kin Mang, Liu Herman S Y, Chan Joyce C W, Hui Angela B Y, Lo Kwok Wai, Jiang Hua, Hou Jian, Chu Raymond W, Wong Wai Shan, Chan Natalie P H, Ng Ho Keung
Abstract excerpt
In this study, we have elucidated the chromosomal imbalances in the multistep pathogenesis and delineated several critical tumor suppressor gene (TSG) loci in multiple myeloma (MM). By using comparative genomic hybridization, allelotyping, and multicolor interphase fluorescence in situ hybridization, 5 MM cell lines and bone marrow CD138+ plasma cells from 88 Chinese patients with monoclonal gammopathy of...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Cell Line, Tumor
- Cell Transformation, Neoplastic
- Chromosomes, Human, Pair 13
- Chromosomes, Human, Pair 4
- DNA Methylation
- Disease Progression