Article
Fibroblasts from phenotypically normal palmar fascia exhibit molecular profiles highly similar to fibroblasts from active disease in Dupuytren's Contracture.
BMC medical genomics - 4 May 2012
Satish Latha, LaFramboise William A, Johnson Sandra, Vi Linda, Njarlangattil Anna, Raykha Christina, Krill-Burger John Michael, Gallo Phillip H, O'Gorman David B, Gan Bing Siang, Baratz Mark E, Ehrlich Garth D, Kathju Sandeep
Abstract excerpt
BACKGROUND: Dupuytren's contracture (DC) is a fibroproliferative disorder characterized by the progressive development of a scar-like collagen-rich cord that affects the palmar fascia of the hand and leads to digital flexion contractures. DC is most commonly treated by surgical resection of the diseased tissue, but has a high reported recurrence rate ranging from 27% to 80%. We sought to determine if the...
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