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Article

Identification of biomarkers in Dupuytren's disease by comparative analysis of fibroblasts versus tissue biopsies in disease-specific phenotypes.

The Journal of hand surgery - 1 Jan 2009

Shih Barbara, Wijeratne Dulharie, Armstrong Daniel J, Lindau Tommy, Day Philip, Bayat Ardeshir

Abstract excerpt

PURPOSE: Biomarkers are molecular mediators that can serve as indicators of normal biological processes, pathologic processes, and therapeutic interventions. This study aims to identify potential biomarkers in Dupuytren's disease (DD), a fibroproliferative benign tumor with an unknown etiology and high recurrence after surgery. METHODS: Bioinformatic analytical techniques were employed to identify candidate genes...

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Source

Identifiers

PMID: 19121738
DOI: 10.1016/j.jhsa.2008.09.017

Genes

TNC
ADAM12
POSTN
PRG4
IRX6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Identification of biomarkers in Dupuytren's disease by comparative analysis of fibroblasts versus tissue biopsies in disease-specific phenotypes.PMID 19121738Read ↗

Molecular phenotypic descriptors of Dupuytren's disease defined using informatics analysis of the transcriptome.Semantic proximity Read ↗

Genome-Wide Analysis Using Exon Arrays Demonstrates an Important Role for Expression of Extra-Cellular Matrix, Fibrotic Control and Tissue Remodelling Genes in Dupuytren's DiseaseSemantic proximity Read ↗

Using functional genomics to identify drug targets: a Dupuytren's disease example.Semantic proximity Read ↗

Fibroblasts from phenotypically normal palmar fascia exhibit molecular profiles highly similar to fibroblasts from active disease in Dupuytren's Contracture.Semantic proximity Read ↗

A Genome-wide Association Study of Dupuytren Disease Reveals 17 Additional Variants Implicated in Fibrosis.Semantic proximity Read ↗

Deciphering Mesenchymal Drivers of Human Dupuytren’s Disease at Single-Cell LevelSemantic proximity Read ↗

Identification of differentially expressed genes in fibroblasts derived from patients with Dupuytren's ContractureSemantic proximity Read ↗

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Recent advances in the understanding of Dupuytren’s diseaseSemantic proximity Read ↗

A meta-analysis of genome-wide association studies in 614,243 individuals identifies 59 novel susceptibility loci underlying Dupuytren’s contractureSemantic proximity Read ↗

Scientific understanding and clinical management of Dupuytren disease.Semantic proximity Read ↗

A genome-wide association meta-analysis implicates Hedgehog and Notch signaling in Dupuytren's disease.Semantic proximity Read ↗

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