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Article

Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes.

PloS one - 1 Jan 2012

Winkler Christiane, Raab Jennifer, Grallert Harald, Ziegler Anette-Gabriele

Abstract excerpt

AIM: To investigate whether type 2 diabetes susceptibility genes and body weight influence the development of islet autoantibodies and the rate of progression to type 1 diabetes. METHODS: Genotyping for single nucleotide polymorphisms (SNP) of the type 2 diabetes susceptibility genes CDKAL1, CDKN2A/2B, FTO, HHEX-IDE, HMGA2, IGF2BP2, KCNJ11, KCNQ1, MTNR1B, PPARG, SLC30A8 and TCF7L2 was obtained in 1350 children...

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Share to Autoimmunity
Share to Body Weight

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 1

Share to Diabetes Mellitus, Type 2

Share to Infant, Newborn

Share to Islets of Langerhans

Share to Statistics, Nonparametric

Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 22558147
DOI: 10.1371/journal.pone.0035410
PMCID: PMC3338842

Genes

CDKAL1
FTO
HHEX
HMGA2
IDE
KCNJ11
KCNQ1
PPARG

Provenance

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes.PMID 22558147Read ↗

No association of multiple type 2 diabetes loci with type 1 diabetes.Semantic proximity Read ↗

Association analysis of type 2 diabetes Loci in type 1 diabetes.Semantic proximity Read ↗

TCF7L2 Genetic Variants Do Not Influence Insulin Sensitivity or Secretion Indices in Autoantibody-Positive Individuals at Risk for Type 1 Diabetes.Semantic proximity Read ↗

Is islet autoimmunity related to insulin sensitivity or body weight in children of parents with type 1 diabetes?Semantic proximity Read ↗

Growth and development of islet autoimmunity and type 1 diabetes in children genetically at risk.Semantic proximity Read ↗

Dissecting heterogeneity in paediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low-risk human leukocyte antigen (HLA) genotypes.Semantic proximity Read ↗

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.Semantic proximity Read ↗

Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes.Semantic proximity Read ↗

Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.Semantic proximity Read ↗

Associations of breastfeeding with childhood autoimmunity, allergies, and overweight: The Environmental Determinants of Diabetes in the Young (TEDDY) study.Semantic proximity Read ↗

HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes.Semantic proximity Read ↗

Type 2 diabetes risk alleles are associated with reduced size at birth.Semantic proximity Read ↗

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