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Is islet autoimmunity related to insulin sensitivity or body weight in children of parents with type 1 diabetes?

Diabetologia - 1 Oct 2009

Winkler C, Marienfeld S, Zwilling M, Bonifacio E, Ziegler A-G

Abstract excerpt

AIMS/HYPOTHESIS: It has been suggested that metabolic demand and insulin resistance play a role in the development of type 1 diabetes, including the onset of autoimmunity. The aim of the present study was to determine whether insulin demand is increased in children with islet autoantibodies. METHODS: BMI standard deviation score (BMI-SDS) was measured from 2 years of age in 1,650 prospectively followed children...

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PMID: 19641897
DOI: 10.1007/s00125-009-1461-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Is islet autoimmunity related to insulin sensitivity or body weight in children of parents with type 1 diabetes?PMID 19641897Read ↗

Growth and development of islet autoimmunity and type 1 diabetes in children genetically at risk.Semantic proximity Read ↗

Early infant growth is associated with the risk of islet autoimmunity in genetically susceptible children.Semantic proximity Read ↗

Elevations in blood glucose before and after the appearance of islet autoantibodies in children.Semantic proximity Read ↗

Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes.Semantic proximity Read ↗

Insulin secretion and sensitivity in the prediction of type 1 diabetes in children with advanced β-cell autoimmunity.Semantic proximity Read ↗

Increased maternal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) associated with older age at diagnosis of Type 1 diabetes in offspring.Semantic proximity Read ↗

Association between family history, early growth and the risk of beta cell autoimmunity in children at risk for type 1 diabetes.Semantic proximity Read ↗

Accelerated progression from islet autoimmunity to diabetes is causing the escalating incidence of type 1 diabetes in young children.Semantic proximity Read ↗

Neuronal T-cell autoreactivity is amplified in overweight children with new-onset insulin-requiring diabetes.Semantic proximity Read ↗

First-phase insulin response in young healthy children at genetic and immunological risk for Type I diabetes.Semantic proximity Read ↗

Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes.Semantic proximity Read ↗

The prevalence of insulin autoantibodies at the onset of Type 1 diabetes is higher in males than females during adolescenceSemantic proximity Read ↗

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