Article
Use of massively parallel pyrosequencing to evaluate the diversity of and selection on Plasmodium falciparum csp T-cell epitopes in Lilongwe, Malawi.
The Journal of infectious diseases - 15 Aug 2012
Bailey Jeffrey A, Mvalo Tisungane, Aragam Nagesh, Weiser Matthew, Congdon Seth, Kamwendo Debbie, Martinson Francis, Hoffman Irving, Meshnick Steven R, Juliano Jonathan J
Abstract excerpt
The development of an effective malaria vaccine has been hampered by the genetic diversity of commonly used target antigens. This diversity has led to concerns about allele-specific immunity limiting the effectiveness of vaccines. Despite extensive genetic diversity of circumsporozoite protein (CS), the most successful malaria vaccine is RTS/S, a monovalent CS vaccine. By use of massively parallel pyrosequencing,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.