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DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage

26 Jun 2012

Abstract excerpt

Human DBC1 (deleted in breast cancer-1; KIAA1967) is a nuclear protein that, in response to DNA damage, competitively inhibits the NAD(+)-dependent deacetylase SIRT1, a regulator of p53 apoptotic functions in response to genotoxic stress. DBC1 depletion in human cells increases SIRT1 activity, resulting in the deacetylation of p53 and protection from apoptosis. However, the mechanisms regulating this process have...

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PMID: 22735644
DOI: 10.1093/jmcb/mjs035

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