Article

LNX1 Modulates Notch1 Signaling to Promote Expansion of the Glioma Stem Cell Population During Temozolomide Therapy in Glioblastoma

2020-09-11

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma (GBM) is the most common primary brain malignancy in adults, with a 100% recurrence rate and a 21-month median survival. Our lab and others have shown that GBM contains a subpopulation of glioma stem cells (GSCs) that expand with chemotherapy, and that may contribute to therapeutic resistance and recurrence in GBM. To investigate the mechanism behind this expansion, we applied gene...

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Literature Corpus work: a007e3c3-369a-59e4-813c-4029a0715ba5
DOI: 10.1101/2020.09.10.287904

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