Article
Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study.
Carcinogenesis - 1 Apr 2007
Mitrou Panagiota N, Watson Mark A, Loktionov Alexandre S, Cardwell Christopher, Gunter Marc J, Atkin Wendy S, Macklin Christopher P, Cecil Tom, Bishop D Timothy, Primrose John, Bingham Sheila A
Abstract excerpt
NADP(H):quinone oxidoreductase 1 (NQO1) and microsomal epoxide hydrolase (EPHX1, also mEH) are attractive candidate enzymes for association with colorectal neoplasia because they metabolize a number of compounds including polycyclic aromatic hydrocarbons (PAHs) that have been linked with colorectal carcinogenesis. We examined the relationship between NQO1C609T, mEH3, mEH4 and risk of sporadic distal colorectal...
Topics
- Adenoma
- Aged
- Alcohol Drinking
- Case-Control Studies
- Colorectal Neoplasms
- Diet
- Epoxide Hydrolases
- Female
- Genetic Predisposition to Disease
- Genotype