Article
Using gene-environment interaction analyses to clarify the role of well-done meat and heterocyclic amine exposure in the etiology of colorectal polyps.
The American journal of clinical nutrition - 1 Nov 2012
Fu Zhenming, Shrubsole Martha J, Li Guoliang, Smalley Walter E, Hein David W, Chen Zhi, Shyr Yu, Cai Qiuyin, Ness Reid M, Zheng Wei
Abstract excerpt
BACKGROUND: The role of well-done meat intake and meat-derived mutagen heterocyclic amine (HCA) exposure in the risk of colorectal neoplasm has been suggested but not yet established. OBJECTIVE: With the use of gene-environment interaction analyses, we sought to clarify the association of HCA exposure with colorectal polyp risk. DESIGN: In a case-control study including 2057 colorectal polyp patients and 3329...
Topics
- Adenoma
- Adult
- Aged
- Alleles
- Amines
- Animals
- Case-Control Studies
- Colonic Polyps
- Colorectal Neoplasms
- DNA, Neoplasm
- Female
- Gene-Environment Interaction
- Humans
- Male