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Article

iRhom2 is required for the secretion of mouse TNFα.

Blood - 14 Jun 2012

Siggs Owen M, Xiao Nengming, Wang Ying, Shi Hexin, Tomisato Wataru, Li Xiaohong, Xia Yu, Beutler Bruce

Abstract excerpt

TNFα is a powerful inflammatory stimulus, central both to the control of infection, and as an agent of inflammatory disease. The most potent inducers of TNFα secretion signal through the Toll-like receptors, and we describe here a chemically-induced mutation that impairs this response in macrophages. A missense mutation was revealed in the gene encoding the inactive rhomboid protease iRhom2, which was not...

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Identifiers

PMID: 22550345
DOI: 10.1182/blood-2012-03-417949
PMCID: PMC3382936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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