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Article

Reliable detection of subclonal single-nucleotide variants in tumour cell populations.

Nature communications - 1 May 2012

Gerstung Moritz, Beisel Christian, Rechsteiner Markus, Wild Peter, Schraml Peter, Moch Holger, Beerenwinkel Niko

Abstract excerpt

According to the clonal evolution model, tumour growth is driven by competing subclones in somatically evolving cancer cell populations, which gives rise to genetically heterogeneous tumours. Here we present a comparative targeted deep-sequencing approach combined with a customised statistical algorithm, called deepSNV, for detecting and quantifying subclonal single-nucleotide variants in mixed populations. We...

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Source

Identifiers

PMID: 22549840
DOI: 10.1038/ncomms1814

Genes

VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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