Article
Lurcher Purkinje cells express glutamic acid decarboxylase and calbindin mRNAs.
Journal of neuroscience research - 1 Sept 1990
Wuenschell C W, Messer A, Tobin A J
Abstract excerpt
Purkinje neurons in immature Lurcher (Lc/+) mice are destined to die as a result of a defect intrinsic to the dying cells. We have used in situ hybridization to determine whether the Lc allele interferes with the normal program of gene expression in the doomed Purkinje cells. In P21 mice, degener...
Topics
- Alleles
- Animals
- Calbindin 1
- Calbindins
- Cell Survival
- DNA
- DNA Probes
- Enkephalins
- Gene Expression Regulation
- Genes, Dominant
- Glutamate Decarboxylase
- Mice
- Mice, Neurologic Mutants
- Nucleic Acid Hybridization
- Protein Precursors
- Purkinje Cells
- RNA, Messenger
- S100 Calcium Binding Protein G