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Article

Specific JNK inhibition by D-JNKI1 protects Purkinje cells from cell death in Lurcher mutant mouse.

Cerebellum (London, England) - 1 Jan 2008

Repici Mariaelena, Zanjani Hadi S, Gautheron Vanessa, Borsello Tiziana, Dusart Isabelle, Mariani Jean

Abstract excerpt

In the Lurcher mutant mouse (+/Lc), Purkinje cells (PCs) selectively die due to the mutation that converts alanine to threonine in the glutamate ionotropic receptor GRID 2, thus resulting in a constitutively leaky cation channel. This intrinsic cell death determines a target-dependent cell death...

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Source

Identifiers

PMID: 18949529
DOI: 10.1007/s12311-008-0070-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18949529-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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