Article
Translocation of cytochrome c during cerebellar degeneration in Lurcher and weaver mutant mice.
Brain research bulletin - 11 Dec 2006
Frischmuth Sabine, Kranda Karel, Bäurle Jörg
Abstract excerpt
Cytochrome c translocation from the inner mitochondrial membrane into the cytosol is the initial step of the intrinsic apoptotic pathway. As no evidence was ever presented for cytochrome c translocation during cerebellar degeneration in Lurcher (Lc/+) and weaver (wv/wv) mutant mice, we searched for the presence of such a process in cerebellar homogenates of mutant and wild-type mice from postnatal day (P)1 to...
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