Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin.

doi:10.1158/1078-0432.CCR-04-1497

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Article

Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2005

Yonemori Kan, Ueno Hideki, Okusaka Takuji, Yamamoto Noboru, Ikeda Masafumi, Saijo Nagahiro, Yoshida Teruhiko, Ishii Hiroshi, Furuse Junji, Sugiyama Emiko, Kim Su-Ryang, Kikura-Hanajiri Ruri, Hasegawa Ryuichi, Saito Yoshiro, Ozawa Shogo, Kaniwa Nahoko, Sawada Jun-Ichi

Abstract excerpt

PURPOSE: We investigated single-nucleotide polymorphisms of the cytidine deaminase gene (CDA), which encodes an enzyme that metabolizes gemcitabine, to clarify the relationship between the single-nucleotide polymorphism 208G>A and the pharmacokinetics and toxicity of gemcitabine in cancer patients treated with gemcitabine plus cisplatin. EXPERIMENTAL DESIGN: Six Japanese cancer patients treated with gemcitabine...

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PMID: 15814642
DOI: 10.1158/1078-0432.CCR-04-1497

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