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Article

Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.

The Journal of biological chemistry - 1 Oct 2010

Li Hongmei, Wang Zilai, Wang Baiping, Guo Qinxi, Dolios Georgia, Tabuchi Katsuhiko, Hammer Robert E, Südhof Thomas C, Wang Rong, Zheng Hui

Abstract excerpt

Proteolytic processing of the amyloid precursor protein (APP) generates large soluble APP derivatives, β-amyloid (Aβ) peptides, and APP intracellular domain. Expression of the extracellular sequences of APP or its Caenorhabditis elegans counterpart has been shown to be sufficient in partially res...

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Source

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Identifiers

PMID: 20693289
DOI: 10.1074/jbc.M110.137729
PMCID: PMC2945554

Genes

APP
APLP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20693289-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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