Article
Haplotype variability in mitochondrial rRNA predisposes to metabolic syndrome.
Communications biology - 11 Sept 2024
Pecina Petr, Čunátová Kristýna, Kaplanová Vilma, Puertas-Frias Guillermo, Šilhavý Jan, Tauchmannová Kateřina, Vrbacký Marek, Čajka Tomáš, Gahura Ondřej, Hlaváčková Markéta, Stránecký Viktor, Kmoch Stanislav, Pravenec Michal, Houštěk Josef, Mráček Tomáš, Pecinová Alena
Abstract excerpt
Metabolic syndrome is a growing concern in developed societies and due to its polygenic nature, the genetic component is only slowly being elucidated. Common mitochondrial DNA sequence variants have been associated with symptoms of metabolic syndrome and may, therefore, be relevant players in the genetics of metabolic syndrome. We investigate the effect of mitochondrial sequence variation on the metabolic...
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