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Update on Surveillance Guidelines in Emerging Wilms Tumor Predisposition Syndromes.

Clinical cancer research : an official journal of the American Association for Cancer Research - 6 Jan 2025

Brzezinski Jack J, Becktell Kerri D, Bougeard Gaëlle, Brodeur Garrett M, Diller Lisa R, Doria Andrea S, Hansford Jordan R, Kohlmann Wendy K, Kratz Christian P, MacFarland Suzanne P, Pajtler Kristian W, Rednam Surya P, Schienda Jaclyn, States Lisa J, Villani Anita, Weksberg Rosanna, Zelley Kristin, Tomlinson Gail E, Kalish Jennifer M

Abstract excerpt

Wilms tumors are commonly associated with predisposition syndromes. Many of these syndromes are associated with specific phenotypic features and are discussed in the related article from the AACR Pediatric Cancer Working Group. Guidelines for surveillance in this population were published in 2017, but since then several studies have identified new genes with recurrent pathogenic variants associated with increased...

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PMID: 39466169
DOI: 10.1158/1078-0432.CCR-24-2488

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