Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C.

doi:10.1016/j.cgh.2012.11.022

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Article

Effects of IL28B rs12979860 CC genotype on metabolic profile and sustained virologic response in patients with genotype 1 chronic hepatitis C.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Mar 2013

Petta Salvatore, Rosso Chiara, Leung Reynold, Abate Maria Lorena, Booth David, Salomone Federico, Gambino Roberto, Rizzetto Mario, Caviglia Paolo, Smedile Antonina, Grimaudo Stefania, Cammà Calogero, Craxì Antonio, George Jacob, Bugianesi Elisabetta

Abstract excerpt

BACKGROUND & AIMS: Patients with genotype 1 chronic hepatitis C (G1 CHC) frequently develop steatosis and insulin resistance (IR), caused by metabolic and viral factors. These accelerate the progression of liver disease and reduce the response to therapy. A sustained virologic response (SVR) to therapy in patients with G1 CHC is associated strongly with polymorphisms near the interleukin-28B (IL28B) gene, but the...

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PMID: 23220171
DOI: 10.1016/j.cgh.2012.11.022

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