Article

Gastrodin ameliorates synaptic impairment, reestablishes mitochondrial membrane potential and reduces oxidative stress in N2a/APP cells through ERK1/2 and GSK-3β pathways

2023-01-18

Abstract excerpt

Alzheimer’s disease (AD) is featured by abnormal β-amyloid (Aβ) deposition, neurofibrillary tangle formation, downstream mitochondrial dysfunction, oxidative stress, and synaptic loss. Gastrodin, a phenolic glycoside, has shown neuroprotective effect and used in the treatment of a range of brain diseases. Here we aim to assess the mechanisms and signaling pathways involved in the neuroprotective effect of gastrodi...

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Literature Corpus work: 334b1fa1-c95b-5eb1-b525-16f715997c48
DOI: 10.1101/2023.01.15.524095

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