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Article

Stimulation of non-amyloidogenic processing of amyloid-β protein precursor by cryptotanshinone involves activation and translocation of ADAM10 and PKC-α.

Journal of Alzheimer's disease : JAD - 1 Jan 2011

Durairajan Siva Sundara Kumar, Liu Liang-Feng, Lu Jia-Hong, Koo Irene, Maruyama Kei, Chung Sookja K, Huang Jian-Dong, Li Min

Abstract excerpt

Cerebral deposition of amyloid-β peptide (Aβ) plaques is now considered the central feature of Alzheimer's disease. Recent studies suggest that cryptotanshinone (CTS) extracted from the root of Salvia miltiorrhiza Bunge could be used for the prevention and treatment of Alzheimer's disease. In this study, we investigated the role of CTS on non-amyloidogenic processing of amyloid-β protein precursor (AβPP) as well...

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Source

Identifiers

PMID: 21403388
DOI: 10.3233/JAD-2011-102085

Genes

ADAM10

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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