Article
A modifier screen in the Drosophila eye reveals that aPKC interacts with Glued during central synapse formation.
BMC genetics - 30 Nov 2009
Ma Lisha, Johns Louise A, Allen Marcus J
Abstract excerpt
BACKGROUND: The Glued gene of Drosophila melanogaster encodes the homologue of the vertebrate p150Glued subunit of dynactin. The Glued1 mutation compromises the dynein-dynactin retrograde motor complex and causes disruptions to the adult eye and the CNS, including sensory neurons and the formation of the giant fiber system neural circuit. RESULTS: We performed a 2-stage genetic screen to identify mutations that...
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