Article
A modifier screen in the Drosophila eye reveals that aPKC interacts with Glued during central synapse formation.
BMC genetics - 30 Nov 2009
Ma Lisha, Johns Louise A, Allen Marcus J
Abstract excerpt
BACKGROUND: The Glued gene of Drosophila melanogaster encodes the homologue of the vertebrate p150Glued subunit of dynactin. The Glued1 mutation compromises the dynein-dynactin retrograde motor complex and causes disruptions to the adult eye and the CNS, including sensory neurons and the formation of the giant fiber system neural circuit. RESULTS: We performed a 2-stage genetic screen to identify mutations that...
Topics
- Animals
- Cell Polarity
- Drosophila Proteins
- Drosophila melanogaster
- Eye
- Female
- Gene Expression Regulation
- Genetic Testing
- Male
- Microtubule-Associated Proteins
- Mutation
- Phenotype
- Protein Kinase C
- Repressor Proteins
- Synapses