Radiation-induced lymphopenia during chemoradiation therapy for non-small cell lung cancer is linked with age, lung V5, and XRCC1 rs25487 genotypes in lymphocytes.

doi:10.1016/j.radonc.2020.09.002

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Article

Radiation-induced lymphopenia during chemoradiation therapy for non-small cell lung cancer is linked with age, lung V5, and XRCC1 rs25487 genotypes in lymphocytes.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Jan 2021

Xie Xiaoxue, Lin Steven H, Welsh James W, Wei Xiong, Jin Hekun, Mohan Radhe, Liao Zhongxing, Xu Ting

Abstract excerpt

BACKGROUND & PURPOSE: We investigated clinical and genetic factors associated with severe radiation-induced lymphopenia (RIL) in a randomized clinical trial of photon vs. proton radiation, with chemotherapy, for non-small cell lung cancer. METHODS: XRCC1 rs25487 was genotyped in lymphocytes from serial peripheral blood samples. Severe RIL was defined as absolute lymphocyte count (ALC) < 0.3 × 109 cells/L....

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Identifiers

PMID: 32916236
DOI: 10.1016/j.radonc.2020.09.002
PMCID: PMC8063970

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XRCC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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