Article
Nef HIV-1 (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus-1), multifunctional protein: features of genetic virus variants circulating in Russia.
Voprosy virusologii - 28 Dec 2025
Kuznetsova A I, Antonova A A, Protasova L A, Glyakina A V, Kim K V, Munchak I M, Mezhenskaya E N, Orlova-Morozova E A, Pronin A Y, Prilipov A G, Galzitskaya O V
Abstract excerpt
INTRODUCTION: Nef provides high level of HIV-1 replication due to synergy of its multiple functions and is an important factor in the pathogenesis of HIV infection. Nef is considered as a target for development of therapeutic agents. Mutations of drug resistance to dolutegravir can occur in Nef protein. Natural amino acid substitutions in Nef protein have been associated with the degree of progression of HIV...
Topics
- Humans
- HIV-1
- nef Gene Products, Human Immunodeficiency Virus
- HIV Infections
- Russia
- Piperazines
- Drug Resistance, Viral
- Dolutegravir
- Genetic Variation
- Pyridones