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Article

Peptide affinity for MHC influences the phenotype of CD8(+) T cells primed in vivo.

Cellular immunology - 25 Nov 2001

Ma H, Kapp J A

Abstract excerpt

Priming C57BL/6 mice with dominant antigenic peptides of ovalbumin (OVA) or bovine insulin (INS) in complete Freund's adjuvant generates antigen-specific, H-2K(b)-restricted, CD8(+) CTL. OVA-CTL produced type 1 cytokines IFN-gamma and TNF-alpha, whereas INS-CTL produced IL-5 and IL-10 with low levels of IL-4 and IFN-gamma. Here, we investigate whether differential binding affinities of the OVA and INS peptides to...

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Source

Identifiers

PMID: 11902833
DOI: 10.1006/cimm.2001.1884

Genes

INS
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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