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Article

TRF2 Controls Telomeric Nucleosome Organization in a Cell Cycle Phase-Dependent Manner

20 Apr 2012

Abstract excerpt

Mammalian telomeres stabilize chromosome ends as a result of their assembly into a peculiar form of chromatin comprising a complex of non-histone proteins named shelterin. TRF2, one of the shelterin components, binds to the duplex part of telomeric DNA and is essential to fold the telomeric chromatin into a protective cap. Although most of the human telomeric DNA is organized into tightly spaced nucleosomes,...

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PMID: 22536324
DOI: 10.1371/journal.pone.0034386

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