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Article

Symptom dimensions as alternative phenotypes to address genetic heterogeneity in schizophrenia and bipolar disorder.

European journal of human genetics : EJHG - 1 Nov 2012

Labbe Aurélie, Bureau Alexandre, Moreau Isabel, Roy Marc-André, Chagnon Yvon, Maziade Michel, Merette Chantal

Abstract excerpt

This study introduces a novel way to use the lifetime ratings of symptoms of psychosis, mania and depression in genetic linkage analysis of schizophrenia (SZ) and bipolar disorder (BP). It suggests using a latent class model developed for family data to define more homogeneous symptom subtypes that are influenced by a smaller number of genes that will thus be more easily detectable. In a two-step approach, we...

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Source

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Identifiers

PMID: 22535187
DOI: 10.1038/ejhg.2012.67
PMCID: PMC3476706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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