Article
Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Dec 2011
Hamshere Marian L, Holmans Peter A, McCarthy Geraldine M, Jones Lisa A, Murphy Kieran C, Sanders Robert D, Gray Marion Y, Zammit Stanley, Williams Nigel M, Norton Nadine, Williams Hywel J, McGuffin Peter, O'Donovan Michael C, Craddock Nicholas, Owen Michael J, Cardno Alastair G
Abstract excerpt
Genetic factors are likely to influence clinical variation in schizophrenia, but it is unclear which variables are most suitable as phenotypes and which molecular genetic loci are involved. We evaluated clinical variable phenotypes and applied suitable phenotypes in genome-wide covariate linkage analysis. We ascertained 170 affected relative pairs (168 sibling-pairs and two avuncular pairs) with DSM-IV...
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