Article
The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia.
Schizophrenia bulletin - 1 Nov 2008
DeRosse Pamela, Lencz Todd, Burdick Katherine E, Siris Samuel G, Kane John M, Malhotra Anil K
Abstract excerpt
OBJECTIVE: Genetic linkage studies in schizophrenia (SZ) have primarily focused on the phenotype of disease susceptibility. A limited number of studies, however, have reported suggestive linkage to specific SZ symptom domains including regions on chromosomes 6, 8, and 20. We examined these chromosomal regions for association to positive, negative, and disorganized symptom clusters, using a dense set of...
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