Article
PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20.
Cellular immunology - 1 Jan 2000
Nicholson Ian C, Mavrangelos Christos, Bird Daniel R G, Bresatz-Atkins Suzanne, Eastaff-Leung Nicola G, Grose Randall H, Gundsambuu Batjargal, Hill Danika, Millard Debbrah J, Sadlon Timothy J, To Sarah, Zola Heddy, Barry Simon C, Krumbiegel Doreen
Abstract excerpt
The peptidase inhibitor PI16 was shown previously by microarray analysis to be over-expressed by CD4-positive/CD25-positive Treg compared with CD4-positive/CD25-negative Th cells. Using a monoclonal antibody to the human PI16 protein, we found that PI16-positive Treg have a memory (CD45RO-positive) phenotype and express higher levels of FOXP3 than PI16-negative Treg. PI16-positive Treg are functional in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.