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Article

Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t.

Proceedings of the National Academy of Sciences of the United States of America - 26 May 2009

Ayyoub Maha, Deknuydt Florence, Raimbaud Isabelle, Dousset Christelle, Leveque Lucie, Bioley Gilles, Valmori Danila

Abstract excerpt

Recent studies have suggested a close relationship between CD4(+)FOXP3(+) regulatory T cells (Tregs) and proinflammatory IL-17-producing T helper cells (T(H)17) expressing the lineage-specific transcription factor RORgamma t. We report here the unexpected finding that human memory Tregs secrete IL-17 ex vivo and constitutively express RORgamma t. IL-17-secreting Tregs share some phenotypic and functional features...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19439651
DOI: 10.1073/pnas.0900621106
PMCID: PMC2688993

Genes

FOXP3
CCR4
CCR6
CXCR3
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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